Qualcosa di bello e di cui essere contenti

È più difficile fare una #torta perfetta o una torta "sbagliata"?

La #terra è sferica, ma non è una sfera perfetta: il raggio terrestre all’#equatore è di circa 6.378 km, mentre ai #poli è “solo” di 6.356 km. Per questo motivo, contrariamente a quanto molti credono, la cima dell'#everest non è il punto della superficie più lontano dal centro della terra. Tu sai qual è questo punto?
#curiosiclubbez #virale #natura #vita #clubbez

Bioavailability Enhancement Technologies

A study conducted on terminated drug development projects revealed that majority of the drug candidates fail in early drug development phases, due to the problems associated with their pharmacokinetic profiles, ADME properties and toxicity-related issues.

Moreover, it is a well-established fact that the systemic / local absorption and distribution of a therapeutic intervention is directly proportional to its bioavailability. In this context, it is also worth highlighting that more than 90% of new chemical entities (NCEs) developed by pharmaceutical companies and nearly 40% of the top-ranking oral drugs marketed in North America and Europe are insoluble in water and, hence, their low solubility can lead to deficient drug concentration, which further leads to in vivo failure. As a result, a large number of companies are now considering adopting various types of bioavailability enhancement technologies in order to ensure that their proprietary pharmacological product candidates are made bioavailable at optimal quantities at the desired site of action.
However, in addition to being a time and cost intensive process, bioavailability enhancement is often fraught with several challenges and considering the expertise available with specialty service providers to improve the pharmacokinetic properties of novel molecules, drug developers are actively outsourcing their requirements.

Diverse Landscape of Bioavailability Enhancement Technology and Service Providers
During our research, we came across nearly 115 players, which claim to offer technologies and services for bioavailability enhancement of drug products / candidates. As per our analysis, North America and Europe, with the highest number of technology as well as service providers, have emerged as key hubs. Further, across all regions, majority of the companies are well established.
Which Company has an Edge Over Other Companies?
Several bioavailability enhancement service providers are constantly making efforts to expand current capabilities to enhance their respective product portfolios and comply to evolving industry benchmarks.
Recent activity in Bioavailability Enhancement Market
At present, the bioavailability enhancement technology and service providers are actively trying to consolidate their presence in this field by entering into strategic alliances, to meet the indubitably rising demand for effective therapeutics. For this purpose, substantial mergers and acquisitions have been reported in this market, as service providers strive to become one-stop-shops, to cater to the diverse needs for their clientele.
Current Annual Demand for Bioavailability Technologies and Services
Considering the concerns related to low solubility / permeability of certain marketed drugs and a large number of NCEs, the demand for bioavailability enhancement technologies and services is anticipated to rise in the future, with a CAGR of ~10%.

Technology Evaluation Framework
With the market evolving at a steady pace, emerging players need to incorporate innovative bioavailability enhancement technologies to augment their service portfolio and surpass the competition. To address these concerns, we have proposed a proprietary framework.
Technology evaluation framework provides a value addition matrix for bioavailability enhancement approaches currently employed by industry stakeholders. The framework highlights the implementation of several advanced as well as traditional bioavailability enhancement approaches and technologies at different stages of the drug development pathway. Further, it provides a detailed analysis on ease of implementation and associated risk in integrating such technologies, based on technology efficacy / success rate, approved drugs, extent of innovation, global competition, and trends in research activity.

For additional details, please visit
https://www.rootsanalysis.com/....blog/bioavailability or email sales@rootsanalysis.com

You may also be interested in the following titles:
1. Smart Labels Market: Industry Trends and Global Forecasts, 2022-2035
2. 4D Bioprinting Market : Industry Trends and Global Forecasts, 2022-2035


About Roots Analysis
Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

Contact:
Ben Johnson
+1 (415) 800 3415
Ben.johnson@rootsanalysis.com

Sanji riesce ad essere un maniaco perfino nei #murales!
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Molte persone hanno la preoccupazione che nel proprio #cibo, soprattutto nella #carne, possano trovarsi degli #antibiotici. In questo articolo spieghiamo come è iniziato il connubio tra antibiotici e #zootecnia e perché non sia necessario preoccuparsi al riguardo.

link: https://clubbez.shop/2023/02/2....0/antibiotici-negli-

Nel #mondo si sprecano circa 1.555 milioni di tonnellate di #cibo l’anno, di cui quasi 2 milioni solo in #italia. Tu fai attenzione allo #sprecoalimentare?
#curiosiclubbez #inquinamento #virale #ambiente #vita #sostenibilità #spreco #clubbez

Liposomes Development: Service Providers Landscape


In recent years, liposomes have garnered significant interest of researchers, as well as industry players, owing to their potential in diagnosis and treatment of various diseases, with a focus on delivering drugs and genetic material.

Liposomes are small, artificial and lipid-based bilayered spherical vesicles, which are created spontaneously by hydrated phospholipids. Owing to their ability to encapsulate bioactive hydrophilic, amphipathic, and lipophilic molecules, liposomes are extensively used as efficient delivery systems for antigens or drugs. Presently, outsourcing of liposomes manufacturing related services has become a popular practice. Drug developers are actively outsourcing their operations to specialized repurposed-based service providers, which are known to have the required capabilities and expertise.

Players Offering Liposome Development and Manufacturing Services
Presently, over 70 companies are actively engaged in offering services related to liposomes development and manufacturing, worldwide. Around 75% of the players offer services for liposome formulation development, followed by the players which offer analytical method development (65%) and contract manufacturing services (64%). Further, most of the liposome development and manufacturing service providers (68%) offer services for discovery / research purposes.

Broad Clinical Trial Landscape
Till date, close to 800 clinical studies evaluating various liposome-based therapeutics have been initiated worldwide. Further, the most targeted disease area within oncological disorders is ovarian cancer, with 226 clinical trials registered in the given time period.

Published Scientific Literature: Indicative of the Ongoing pace of Research in this Field
Over the years, there has been a gradual increase in the number of publications related to liposomes. Majority of the articles (51%) are focused on evaluating liposomes for use in cancer therapy. This can be attributed to the fact that liposomes can actively target tumor tissues when used in combination with antibodies.

High Number of Patents are Suggestive of the Widespread Research in this Domain
Several industry and non-industry players are involved in the development and manufacturing of liposomes in order to evaluate their therapeutic and diagnostic potential in the treatment of various diseases. The field has seen a significant rise in the number of patents over the past few years, majority (53.5%) of these patents are applications (not having received approval yet), followed by granted patents (46.2%).

Events related to Liposome Development and Manufacturing, organized Globally
In the past few years, various types of events (webinars / conferences / seminars / workshops / symposiums / summits) were organized to discuss the potential of liposomes as novel drug delivery systems. These platforms have created an opportunity for the product developers to share their innovative ideas in this domain.

Future Evolution of Liposome Development and Manufacturing Services Market
With the rising demand for novel therapeutic modalities, the liposome development and manufacturing services market is anticipated to grow at an annualized rate of around 10% between 2022 and 2035.

Conclusion
Despite several advancements, there are various challenges in development of liposomes, for which stakeholders are leveraging the expertise of various contract service providers offering development and manufacturing services. These service providers are actively upgrading their capabilities and infrastructure to accommodate the demand for these vesicles. Driven by the growing research efforts, development of advanced methods for preparation and characterization of liposomes, and efforts of various stakeholders, this segment of industry is likely to witness noteworthy growth in the foreseen future.

For additional details, please visit
https://www.rootsanalysis.com/....blog/liposomes-devel or email sales@rootsanalysis.com

You may also be interested in the following titles:
1. Smart Labels Market: Industry Trends and Global Forecasts, 2022-2035
2. 4D Bioprinting Market : Industry Trends and Global Forecasts, 2022-2035


About Roots Analysis
Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

Contact:
Ben Johnson
+1 (415) 800 3415
Ben.johnson@rootsanalysis.com

La gente sbaglia a dire che Michael Keaton è tornato a essere Batman semplicemente perché lui non ha mai smesso di esserlo.
#meme #mikaelkeaton #batman #dc
Fonte: gruppo Facebook "Gilgamesh - L'Isola di Asgralot".